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PDLLA: Proven Effective in Restoring Adipose Tissue in Aging Skin
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2025-01-24 16:48
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PDLLA: Proven Effective in Restoring Adipose Tissue in Aging Skin
The paper titled "Poly-D,L-Lactic Acid Fillers Increase Subcutaneous Adipose Tissue Volume by Promoting Adipogenesis in Aged Animal Skin" was published on November 27 of last year in the SCI-level International Journal of Molecular Sciences. The study revealed that PDLLA, the main ingredient of LENISNA, effectively restores the thickness and elasticity of adipose tissue in aging skin.
In this research, it was confirmed that PDLLA fillers stimulate aged macrophages, inducing their polarization into anti-inflammatory M2 macrophages, which in turn promotes the formation of adipocytes. M2 macrophages are known to increase the secretion of Fibroblast Growth Factor 2 (FGF2), a key substance that aids in the survival and proliferation of adipose-derived stem cells (ASCs).
In cell samples injected with PDLLA, FGF2 secretion increased by 70%, and adipocyte formation genes (PPAR-γ and C/EBP-α) showed increases of 65% and 50%. The thickened adipose layer is not a result of increased adipocyte size, but rather due to an increase in the number of adipocytes. It was confirmed that the rise in mature adipocyte count allows for their proper engraftment, leading to the formation of a thicker adipose layer. This demonstrates that PDLLA aids in the proliferation and engraftment of normal adipose tissue cells.
A representative from VAIM stated, “Lenisna, which contains PDLLA as its main ingredient, has shown potential not only in tissue restoration but also in fundamentally improving the aged skin environment. It is expected to play a significant role in facial contour restoration and skin regeneration treatments in the future.”
Introduction of VAIM
Founded in 2014, VAIM is a global medical aesthetics company that develops human tissue regeneration products and improved pharmaceuticals by utilizing its accumulated technology and know-how in biocompatible and biodegradable polymers. It has developed and patented a PDLLA-based manufacturing technology that reduces the risk of nodule formation compared to other ingredient structures, and in 2019, its subsidiary, VAIM Global, entered the skin booster market with JUVELOOK, which utilizes this technology. JUVELOOK is a collagen booster that induces the production of ECM (collagen, elastin) to provide direct remodeling effects on the skin such as elasticity and wrinkle improvement, and is divided into JUVELOOK and LENISNA depending on the purpose. After quickly proving its safety and effectiveness since its launch, VAIM Global currently has product export contracts with 72 countries.